| Level | Date | Time | Home | Opponent | Result | Score | Record |
|---|---|---|---|---|---|---|---|
| Varsity | Aug 20, 2021 | 7:30 PM | away | @ King's Academy | W | 54-23 | 1-0 |
| Varsity | Aug 27, 2021 | 7:30 PM | away | @ Dorchester Academy | W | 52-21 | 2-0 |
| MS | Sep 9, 2021 | 5:00 PM | away | @ Hilton Head Prep | W | 12-6 | 1-0 |
| Varsity | Sep 10, 2021 | 7:00 PM | home | Northwood Academy | W | 15-0 | 3-0 |
| MS | Sep 16, 2021 | 6:30 PM | away | @ Orangeburg Prep | L | 8-6 | 1-1 |
| Varsity | Sep 17, 2021 | 7:00 PM | home | Orangeburg Prep | W | 53-0 | 4-0 |
| MS | Sep 23, 2021 | 5:00 PM | home | Colleton Prep Academy | W | 45-8 | 2-1 |
| Varsity | Sep 24, 2021 | 7:30 PM | away | @ Colleton Prep Academy | W | 49-7 | 5-0 |
| MS | Sep 30, 2021 | 6:00 PM | away | @ Bethesda Academy | W | 24-6 | 3-1 |
| Varsity | Oct 1, 2021 | 7:00 PM | home | Pinewood Prep | W | 48-14 | 6-0 |
| MS | Oct 7, 2021 | 6:00 PM | home | Hilton Head Prep | L | 18-8 | 3-2 |
| Varsity | Oct 8, 2021 | 7:00 PM | home | Bethesda Academy | W | 41-8 | 7-0 |
| MS | Oct 14, 2021 | 5:00 PM | away | @ Thomas Heyward Academy | W | 27-22 | 4-2 |
| Varsity | Oct 14, 2021 | 7:00 PM | away | @ John Paul II | W | 53-12 | 8-0 |
| MS | Oct 21, 2021 | 6:00 PM | away | @ Beaufort Academy | L | 24-8 | 4-3 |
| Varsity | Oct 22, 2021 | 7:00 PM | home | Beaufort Academy | W | 35-6 | 9-0 |
| Varsity | Oct 29, 2021 | 3:30 PM | away | @ Hilton Head Prep | W | 42-0 | 10-0 |
| Varsity | Nov 5, 2021 | 7:00 PM | home | Carolina Academy | W | 47-0 | 11-0 |
| Varsity | Nov 12, 2021 | TBD | home | Pee Dee Academy | W | 52-23 | 12-0 |
| Varsity | Nov 20, 2021 | 5:00 PM | neutral | State Championship vs Williamsburg Academy | W | 34-7 | 13-0 |