| Level | Date | Time | Home | Opponent | Result | Score | Record |
|---|---|---|---|---|---|---|---|
| JV | Nov 18, 2021 | 5:00 PM | away | @ St Vincent's | L | 43-19 | 0-1 |
| Varsity | Nov 18, 2021 | 6:30 PM | away | @ St Vincent's | W | 53-41 | 1-0 |
| Varsity | Nov 22, 2021 | 6:30 PM | away | @ Hammond School | L | 69-65 | 1-1 |
| Varsity | Nov 23, 2021 | 6:30 PM | away | @ Chapin High School | W | 64-26 | 2-1 |
| MS | Nov 29, 2021 | 6:00 PM | neutral | St Francis Tip Off Tournament-- Bridges | W | 42-5 | 1-0 |
| JV | Dec 2, 2021 | 3:30 PM | away | @ Savannah Christian | W | 21-19 | 1-1 |
| MS | Dec 2, 2021 | 5:00 PM | neutral | St Francis Tip Off Tournament-St Gregory | W | 39-5 | 2-0 |
| Varsity | Dec 2, 2021 | 6:30 PM | away | @ Savannah Christian | W | 64-20 | 3-1 |
| MS | Dec 3, 2021 | 6:00 PM | neutral | St Francis Tip Off Tournament- John Paul II | L | 39-10 | 2-1 |
| MS | Dec 6, 2021 | 4:00 PM | home | St Gregory | W | 29-10 | 3-1 |
| Varsity | Dec 7, 2021 | 6:00 PM | home | Bridges Academy | W | 56-12 | 4-1 |
| MS | Dec 10, 2021 | 5:00 PM | away | @ Calvary Day | W | 18-16 | 4-1 |
| MS | Dec 14, 2021 | 4:00 PM | away | @ St Francis | W | 34-23 | 5-1 |
| JV | Dec 20, 2021 | 6:00 PM | home | Coastal Hurricanes | W | 35-17 | 2-1 |
| Varsity | Dec 29, 2021 | 6:30 PM | home | Islands | W | 53-37 | 5-1 |
| Varsity | Dec 30, 2021 | 5:00 PM | home | Richmond Hill High School | W | 56-34 | 6-1 |
| JV | Jan 3, 2022 | 1:00 PM | away | @ Calvary Day | L | 52-12 | 2-2 |
| Varsity | Jan 3, 2022 | 4:00 PM | away | @ Calvary Day | W | 69-61 | 7-1 |
| JV | Jan 4, 2022 | 4:00 PM | home | Colleton Prep Academy | W | 39-4 | 3-2 |
| Varsity | Jan 4, 2022 | 6:00 PM | home | Colleton Prep Academy | W | 50-23 | 8-1 |
| MS | Jan 6, 2022 | 4:30 PM | home | Riverview Charter | W | 23-20 | 6-1 |
| MS | Jan 7, 2022 | 4:00 PM | away | @ Beaufort Academy | W | 48-17 | 7-1 |
| Varsity | Jan 7, 2022 | 6:00 PM | home | Beaufort Academy | W | 89-54 | 9-1 |
| MS | Jan 11, 2022 | 4:00 PM | away | @ Hilton Head Prep | L | 21-18 | 7-2 |
| Varsity | Jan 11, 2022 | 6:00 PM | home | Hilton Head Prep | W | 44-27 | 10-1 |
| JV | Jan 14, 2022 | 4:00 PM | home | John Paul II | W | 100-0 | 4-2 |
| MS | Jan 14, 2022 | 4:00 PM | away | @ John Paul II | L | 25-20 | 7-3 |
| Varsity | Jan 14, 2022 | 6:00 PM | home | John Paul II | W | 54-29 | 11-1 |
| JV | Jan 15, 2022 | 12:00 PM | home | Calvary Day | W | 100-0 | 5-2 |
| Varsity | Jan 15, 2022 | 2:30 PM | home | Calvary Day | L | 52-47 | 11-2 |
| MS | Jan 18, 2022 | 4:00 PM | home | Thomas Heyward Academy | W | 40-16 | 8-3 |
| Varsity | Jan 18, 2022 | 6:00 PM | away | @ Thomas Heyward Academy | W | 60-25 | 12-2 |
| MS | Jan 25, 2022 | 4:00 PM | home | Holy Trinity | W | 27-19 | 9-3 |
| JV | Jan 26, 2022 | 5:00 PM | home | St Vincent's | L | 25-20 | 5-3 |
| MS | Jan 26, 2022 | 6:00 PM | away | @ Cross Episcopal | W | 24-15 | 10-3 |
| Varsity | Jan 26, 2022 | 6:30 PM | home | St Vincent's | W | 56-30 | 13-2 |
| JV | Jan 28, 2022 | 4:00 PM | away | @ Colleton Prep Academy | W | 50-7 | 6-3 |
| MS | Jan 28, 2022 | 4:00 PM | home | Calvary Day | W | 24-23 | 11-3 |
| Varsity | Jan 28, 2022 | 6:00 PM | away | @ Colleton Prep Academy | W | 59-15 | 14-2 |
| MS | Jan 31, 2022 | 6:00 PM | away | @ Savannah Country Day | L | 19-12 | 11-4 |
| MS | Feb 1, 2022 | 4:00 PM | home | Riverview Charter | W | 39-20 | 12-4 |
| Varsity | Feb 1, 2022 | 6:00 PM | away | @ Beaufort Academy | W | 66-34 | 15-2 |
| MS | Feb 4, 2022 | 4:00 PM | home | Hilton Head Prep | W | 25-19 | 13-4 |
| Varsity | Feb 4, 2022 | 6:00 PM | away | @ Hilton Head Prep | W | 51-37 | 16-2 |
| MS | Feb 5, 2022 | 9:00 AM | home | Heritage Academy | W | 38-12 | 14-4 |
| JV | Feb 5, 2022 | 12:00 PM | home | Savannah Christian | W | 22-18 | 7-3 |
| Varsity | Feb 5, 2022 | 2:30 PM | home | Savannah Christian | W | 54-33 | 17-2 |
| JV | Feb 8, 2022 | 4:00 PM | away | @ John Paul II | L | 34-17 | 7-4 |
| MS | Feb 8, 2022 | 4:00 PM | home | John Paul II | W | 21-16 | 15-4 |
| Varsity | Feb 8, 2022 | 6:00 PM | away | @ John Paul II | W | 51-35 | 18-2 |
| MS | Feb 9, 2022 | 4:00 PM | home | St Francis | W | 32-16 | 16-4 |
| MS | Feb 10, 2022 | 4:00 PM | away | @ Thomas Heyward Academy | W | 30-8 | 17-4 |
| Varsity | Feb 10, 2022 | 6:00 PM | home | Thomas Heyward Academy | W | 59-22 | 19-2 |
| MS | Feb 11, 2022 | 4:00 PM | home | Cross School | W | 32-16 | 18-4 |
| JV | Feb 11, 2022 | 4:30 PM | away | @ Beach High School | L | 33-21 | 7-5 |
| Varsity | Feb 11, 2022 | 6:00 PM | away | @ Beach High School | W | 29-27 | 20-2 |
| MS | Feb 14, 2022 | 4:00 PM | away | @ Holy Trinity | W | 31-20 | 19-4 |
| Varsity | Feb 14, 2022 | 5:00 PM | home | Holy Trinity | W | 63-16 | 21-2 |
| MS | Feb 16, 2022 | 4:00 PM | neutral | Hilton Head Prep | L | 14-13 | 19-5 |
| MS | Feb 17, 2022 | TBD | neutral | St Francis | W | 25-15 | 20-5 |
| Varsity | Feb 18, 2022 | TBD | neutral | SCISA AA Playoff Round 1 Williamsburg Academy | W | 73-21 | 22-2 |
| Varsity | Feb 21, 2022 | 5:00 PM | neutral | SCISA AA Playoff Round 2 Greenwood Christian | W | 71-30 | 23-2 |
| Varsity | Feb 24, 2022 | 3:30 PM | neutral | SCISA AA Playoff Semi Finals Palmetto Christian | W | 32-21 | 24-2 |
| Varsity | Feb 26, 2022 | TBD | neutral | SCISA AA Playoff Championship Orangeburg Prep | W | 45-34 | 25-2 |