| Date | Time | Home | Opponent | Result | Score | Record |
|---|---|---|---|---|---|---|
| Nov 18, 2021 | 6:30 PM | away | @ St Vincent's | W | 53-41 | 1-0 |
| Nov 22, 2021 | 6:30 PM | away | @ Hammond School | L | 69-65 | 1-1 |
| Nov 23, 2021 | 6:30 PM | away | @ Chapin High School | W | 64-26 | 2-1 |
| Dec 2, 2021 | 6:30 PM | away | @ Savannah Christian | W | 64-20 | 3-1 |
| Dec 7, 2021 | 6:00 PM | home | Bridges Academy | W | 56-12 | 4-1 |
| Dec 29, 2021 | 6:30 PM | home | Islands | W | 53-37 | 5-1 |
| Dec 30, 2021 | 5:00 PM | home | Richmond Hill High School | W | 56-34 | 6-1 |
| Jan 3, 2022 | 4:00 PM | away | @ Calvary Day | W | 69-61 | 7-1 |
| Jan 4, 2022 | 6:00 PM | home | Colleton Prep Academy | W | 50-23 | 8-1 |
| Jan 7, 2022 | 6:00 PM | home | Beaufort Academy | W | 89-54 | 9-1 |
| Jan 11, 2022 | 6:00 PM | home | Hilton Head Prep | W | 44-27 | 10-1 |
| Jan 14, 2022 | 6:00 PM | home | John Paul II | W | 54-29 | 11-1 |
| Jan 15, 2022 | 2:30 PM | home | Calvary Day | L | 52-47 | 11-2 |
| Jan 18, 2022 | 6:00 PM | away | @ Thomas Heyward Academy | W | 60-25 | 12-2 |
| Jan 26, 2022 | 6:30 PM | home | St Vincent's | W | 56-30 | 13-2 |
| Jan 28, 2022 | 6:00 PM | away | @ Colleton Prep Academy | W | 59-15 | 14-2 |
| Feb 1, 2022 | 6:00 PM | away | @ Beaufort Academy | W | 66-34 | 15-2 |
| Feb 4, 2022 | 6:00 PM | away | @ Hilton Head Prep | W | 51-37 | 16-2 |
| Feb 5, 2022 | 2:30 PM | home | Savannah Christian | W | 54-33 | 17-2 |
| Feb 8, 2022 | 6:00 PM | away | @ John Paul II | W | 51-35 | 18-2 |
| Feb 10, 2022 | 6:00 PM | home | Thomas Heyward Academy | W | 59-22 | 19-2 |
| Feb 11, 2022 | 6:00 PM | away | @ Beach High School | W | 29-27 | 20-2 |
| Feb 14, 2022 | 5:00 PM | home | Holy Trinity | W | 63-16 | 21-2 |
| Feb 18, 2022 | TBD | neutral | SCISA AA Playoff Round 1 Williamsburg Academy | W | 73-21 | 22-2 |
| Feb 21, 2022 | 5:00 PM | neutral | SCISA AA Playoff Round 2 Greenwood Christian | W | 71-30 | 23-2 |
| Feb 24, 2022 | 3:30 PM | neutral | SCISA AA Playoff Semi Finals Palmetto Christian | W | 32-21 | 24-2 |
| Feb 26, 2022 | TBD | neutral | SCISA AA Playoff Championship Orangeburg Prep | W | 45-34 | 25-2 |